What is VPRIV used for?
Velaglucerase is used to treat a certain rare genetic problem (Gaucher disease). Velaglucerase replaces a certain natural substance (an enzyme called glucocerebrosidase) that is missing in people with Gaucher disease. This medication improves blood, bone, liver, and spleen problems caused by Gaucher disease.
Who manufactures VPRIV?
Velaglucerase alfa, sold under the brand name Vpriv and manufactured by Shire plc, is a hydrolytic lysosomal glucocerebroside-specific enzyme, which is a recombinant form of glucocerebrosidase indicated as a long-term enzyme replacement therapy for those suffering of Gaucher disease Type 1.
How much does VPRIV cost?
The cost for VPRIV intravenous powder for injection 400 units is around $1,490 for a supply of 1 powder for injection, depending on the pharmacy you visit….Intravenous Powder For Injection.
| Quantity | Per unit | Price |
|---|---|---|
| 1 | $1,490.21 | $1,490.21 |
How do you administer vpriv?
The recommended starting VPRIV dosage in naive adults and naive pediatric patients 4 years of age and older is 60 Units/kg administered every other week as a 60-minute intravenous infusion. The dosage can be adjusted based on achievement and maintenance of each patient’s therapeutic goals.
What is Gaucher disease type 1?
Gaucher disease type 1: Gaucher disease type 1 is the most common form of the disease in western countries, making up roughly 95 percent of patients there. Symptoms include spleen and liver enlargement, bone problems, and fatigue. Brain development is normal.
How do you administer VPRIV?
How is vpriv made?
The active ingredient of VPRIV is velaglucerase alfa, which is produced by gene activation technology in a human fibroblast cell line. Velaglucerase alfa is a glycoprotein of 497 amino acids; with a molecular weight of approximately 63 kDa.
What are the symptoms of Gaucher disease?
Symptoms of Gaucher disease can include:
- Enlarged spleen.
- Enlarged liver.
- Eye movement disorders.
- Yellow spots in the eyes.
- Not having enough healthy red blood cells (anemia)
- Extreme tiredness (fatigue)
- Bruising.
- Lung problems.
At what age is Gaucher disease diagnosed?
Although the disease can be diagnosed at any age, half of patients are under the age of 20 at diagnosis. The clinical presentation is heterogeneous with occasional asymptomatic forms.
What are the signs and symptoms of Gaucher disease?
What are the symptoms of Gaucher disease?
- Enlarged spleen.
- Enlarged liver.
- Eye movement disorders.
- Yellow spots in the eyes.
- Not having enough healthy red blood cells (anemia)
- Extreme tiredness (fatigue)
- Bruising.
- Lung problems.
How do you measure enzyme levels?
A cardiac enzyme test is a blood test that measures the cardiac enzymes in the blood. A technician will insert a needle into a person’s arm and draw a sample of blood. They will send the sample to a lab where it will be analyzed for cardiac enzymes.
What is the recommended VPRIV dosage for naive patients?
The recommended starting VPRIV dosage in naïve adults and naïve pediatric patients 4 years of age and older is 60 Units/kg administered every other week as a 60-minute intravenous infusion.
What is the recommended starting dosage for enzyme replacement therapy (VPRIV)?
Recommended Starting Dosage in Patients Naïve to Enzyme Replacement Therapy. VPRIV should be administered under the supervision of a healthcare professional. The recommended starting VPRIV dosage in naïve adults and naïve pediatric patients 4 years of age and older is 60 Units/kg administered every other week as a 60-minute intravenous infusion.
VPRIV should be administered under the supervision of a healthcare professional as a 60-minute intravenous infusion. The dosage can be adjusted based on achievement and maintenance of each patient’s therapeutic goals. VPRIV is a lyophilized powder, which requires reconstitution and dilution, using sterile technique, prior to intravenous infusion.
How long does it take for a VPRIV infusion?
VPRIV is injected into a vein through an IV. A healthcare provider will give you this injection. VPRIV must be given slowly, and the IV infusion can take at least 1 hour to complete. VPRIV is usually given every other week.